There are an awful lot of people in Mississippi, Alabama, Louisiana and possibly points further north who will be needing an awful lot of help in the coming days, weeks, and months. And I'm not talking about knitting socks or hats for them either.

If you can afford it, consider donating money to the relief efforts just getting started to assist people affected by Hurricane Katrina. Here's a link full of legitimate charties that can funnel aid to people in need.

UPDATE:

Unless you have a personal contact at someplace that's sheltering refugees, and a guaranteed way to get stuff to them (NOT US Mail, UPS, FedEx or chartered truck) - donate money instead of trying to send goods. Think about it. There's no infrastructure to distribute goods, and there's a far greater need for the assistance personnel down there to do search and rescue, transport of the vulnerable, wounded or sick, than there is for them to sort donated items for distribution.

More places accepting money donations:
American Red Cross
United Way